Effect of reduced oxygen on the antifungal susceptibility of clinically relevant aspergilli

Ulrike Binder; Elisabeth Maurer; Michaela Lackner; Cornelia Lass-Flörl

doi:10.1128/AAC.04204-14

Effect of reduced oxygen on the antifungal susceptibility of clinically relevant aspergilli

Antimicrob Agents Chemother. 2015 Mar;59(3):1806-10. doi: 10.1128/AAC.04204-14. Epub 2014 Dec 29.

Authors

Ulrike Binder¹, Elisabeth Maurer², Michaela Lackner², Cornelia Lass-Flörl²

Affiliations

¹ Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria ulrike.binder@i-med.ac.at.
² Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria.

Abstract

The influence of hypoxia on the in vitro activities of amphotericin B, azoles, and echinocandins against Aspergillus spp. was evaluated by comparing MICs, minimal fungicidal concentrations (MFCs), and epidemiological cutoffs (ECOFFs). Changes of MIC distributions due to hypoxia largely depend on the method, the species, and the growth ability under hypoxia. The activities of antifungals were not significantly altered under hypoxia, except for Aspergillus terreus, for which the activity changed from fungicidal to fungistatic.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / pharmacology*
Aspergillosis / drug therapy
Aspergillosis / microbiology
Aspergillus / drug effects*
Hypoxia / drug therapy
Hypoxia / microbiology
Microbial Sensitivity Tests / methods
Oxygen / pharmacology*

Substances

Antifungal Agents
Oxygen