Is intra-articular hyaluronic acid effective in treating osteoarthritis of the hip joint?

Jay R Lieberman; Stephen M Engstrom; Olga Solovyova; Carol Au; James J Grady

doi:10.1016/j.arth.2013.10.019

Is intra-articular hyaluronic acid effective in treating osteoarthritis of the hip joint?

J Arthroplasty. 2015 Mar;30(3):507-11. doi: 10.1016/j.arth.2013.10.019. Epub 2013 Nov 8.

Authors

Jay R Lieberman¹, Stephen M Engstrom², Olga Solovyova³, Carol Au⁴, James J Grady⁵

Affiliations

¹ Department of Orthopaedic Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California.
² Vanderbilt Orthopaedic Institute, Vanderbilt University Medical Center, Nashville, Tennessee.
³ University of Connecticut School of Medicine, University of Connecticut Health Center, Farmington, Connecticut.
⁴ Biostatistics Center, Connecticut Institute for Clinical and Translational Science University of Connecticut Health Center, Farmington, Connecticut.
⁵ Connecticut Institute for Clinical and Translational Science, University of Connecticut Health Center, Farmington, Connecticut.

PMID: 25542833
DOI: 10.1016/j.arth.2013.10.019

Abstract

Hyaluronic acid (HA) injections are used to treat osteoarthritis of the hip but their efficacy has not been clearly established. The purpose of this meta-analysis was to determine the effect of HA injections on hip pain. There were twenty-three studies that met our criteria and the mean decrease in visual analog scores (VAS) was -1.97 (95% CL, 2.83 to -1.12, P<0.0001). However, the clinical relevance of this change is difficult to determine since the decrease in VAS was only -0.27 in the six randomized trials in the study and the duration of follow-up in most studies was less than six months. Multicenter randomized trials are needed to determine the true efficacy of HA injections in decreasing pain associated with hip osteoarthritis.

Keywords: Synvisc; hip; hyaluronic acid; injection; osteoarthritis.

Publication types

Meta-Analysis
Review

MeSH terms

Hip Joint*
Humans
Hyaluronic Acid / administration & dosage*
Injections, Intra-Articular
Osteoarthritis, Hip / drug therapy*
Treatment Outcome
Viscosupplements / administration & dosage*

Substances

Viscosupplements
Hyaluronic Acid