Percutaneous cryoablation for inoperable malignant lung tumors: midterm results

Hsiao-Ping Chou; Chun-Ku Chen; Shu-Huei Shen; Ming-Huei Sheu; Mei-Han Wu; Yu-Chung Wu; Cheng-Yen Chang

doi:10.1016/j.cryobiol.2014.12.004

Percutaneous cryoablation for inoperable malignant lung tumors: midterm results

Cryobiology. 2015 Feb;70(1):60-5. doi: 10.1016/j.cryobiol.2014.12.004. Epub 2014 Dec 23.

Authors

Hsiao-Ping Chou¹, Chun-Ku Chen², Shu-Huei Shen³, Ming-Huei Sheu⁴, Mei-Han Wu⁴, Yu-Chung Wu⁵, Cheng-Yen Chang⁶

Affiliations

¹ Department of Radiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Taipei 11217, Taiwan.
² Department of Radiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Taipei 11217, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong St., Taipei 11221, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Hospital and Health Care Administration, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: ckchen@vghtpe.gov.tw.
³ Department of Radiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Taipei 11217, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong St., Taipei 11221, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
⁴ Department of Radiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Taipei 11217, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong St., Taipei 11221, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
⁵ Faculty of Medicine, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong St., Taipei 11221, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
⁶ Department of Radiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Taipei 11217, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong St., Taipei 11221, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, Taiwan.

PMID: 25541142
DOI: 10.1016/j.cryobiol.2014.12.004

Abstract

Objective: To retrospectively analyze the efficacy and short- to mid-term survival rate of cryoablation for malignant lung tumors.

Methods: Percutaneous CT-guided cryoablation for 45 malignant lung tumors in 26 patients during 41 sessions from 2009 to 2013 were performed. Follow up CT-scan were used to determine local tumor progression. Survival rate, local tumor control rate and associated risk factors were analyzed.

Results: The immediate during and short-term complications with CTCAE grade 2 or upper include pneumothorax (15%), pleural effusion (20%), pulmonary hemorrhage (24%), pneumonitis (15%), hemothorax (15%), hemoptysis (10%), pain (20%), bronchopleural fistula (n=1), and empyema (n=2). Life-threatening bleeding or hemodynamic instability was not observed. There was no procedural-related mortality. Overall survival rate of 1, 2, 3 years are 96%, 88%, 88%. For curative intent, local tumor control (LTC) rate of 1, 2, 3 years are 75%, 72%, 72%.

Conclusion: Cryoablation for malignant lung tumors is effective and feasible in local control of tumor growth, with good short- to mid-term survival rate, as an alternative option for inoperable patients.

Keywords: Ablation; Cryoablation; Cryotherapy; Image-guided; Lung tumors.

MeSH terms

Aged
Bronchial Fistula / epidemiology
Cryosurgery / adverse effects
Cryosurgery / methods*
Empyema, Pleural / epidemiology
Female
Hemoptysis / epidemiology
Hemothorax / epidemiology
Humans
Lung Neoplasms / mortality
Lung Neoplasms / surgery*
Male
Middle Aged
Pain / epidemiology
Pleural Effusion
Pneumonia
Postoperative Complications / epidemiology
Retrospective Studies
Survival Rate
Tomography, X-Ray Computed
Treatment Outcome