Aqueous based synthesis of antimicrobial-decorated graphene

M Haniff Wahid; Uwe H Stroeher; Ela Eroglu; Xianjue Chen; Kasturi Vimalanathan; Colin L Raston; Ramiz A Boulos

doi:10.1016/j.jcis.2014.11.043

Aqueous based synthesis of antimicrobial-decorated graphene

J Colloid Interface Sci. 2015 Apr 1:443:88-96. doi: 10.1016/j.jcis.2014.11.043. Epub 2014 Nov 25.

Authors

M Haniff Wahid¹, Uwe H Stroeher², Ela Eroglu³, Xianjue Chen⁴, Kasturi Vimalanathan⁵, Colin L Raston⁶, Ramiz A Boulos⁷

Affiliations

¹ Centre for NanoScale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA 5042, Australia. Electronic address: haniff.wahid@flinders.edu.au.
² School of Biological Sciences, Flinders University, Bedford Park, SA 5042, Australia. Electronic address: uwe.stroeher@flinders.edu.au.
³ Centre for Strategic Nano-Fabrication, School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia. Electronic address: ela.eroglu@uwa.edu.au.
⁴ Centre for NanoScale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA 5042, Australia. Electronic address: xianjue.chen@flinders.edu.au.
⁵ Centre for NanoScale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA 5042, Australia. Electronic address: kasturi.vimalanthan@flinders.edu.au.
⁶ Centre for NanoScale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA 5042, Australia. Electronic address: colin.raston@flinders.edu.au.
⁷ Centre for NanoScale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA 5042, Australia. Electronic address: ramiz.boulos@flinders.edu.au.

PMID: 25540825
DOI: 10.1016/j.jcis.2014.11.043

Abstract

Ramizol® (1,3,5-tris[(1E)-2'-(4'-benzoic acid)vinyl]benzene) is a potent amphiphilic anti-microbial agent. It is essentially a planar molecule and can interact with the surface of graphene via extended π-π interactions. Herein we demonstrate the utility of Ramizol® in potentially acting as a molecular 'wedge' to exfoliate graphene and stabilise it in water. The non-covalent attachment of Ramizol® on the graphene surface enables release of Ramizol® by altering the pH of the solution. Furthermore, the stabilised composite material demonstrates antibacterial activity against Staphylococcus aureus which leads to potential in biomedical applications with graphene acting as a drug carrier as well as enhancing the structural strength of the composite material.

Keywords: Antibacterial; Antimicrobial; Exfoliation; Graphene; Non-covalent functionalization; Ramizol; Ultra-sonication.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology*
Benzoates / chemical synthesis*
Benzoates / pharmacology*
Graphite / chemistry*
Microscopy, Atomic Force
Microscopy, Electron, Transmission
Particle Size
Staphylococcal Infections / drug therapy*
Staphylococcal Infections / microbiology
Staphylococcus aureus / drug effects*
Stilbenes / chemical synthesis*
Stilbenes / pharmacology*
Water / chemistry*

Substances

1,3,5-tris(2'-(4'-benzoic acid)vinyl)benzene
Anti-Bacterial Agents
Benzoates
Stilbenes
Water
Graphite