Molecular profiling of Escherichia coli O157:H7 and non-O157 strains isolated from humans and cattle in Alberta, Canada

J Clin Microbiol. 2015 Mar;53(3):986-90. doi: 10.1128/JCM.03321-14. Epub 2014 Dec 24.

Abstract

Virulence markers in Shiga toxin-producing Escherichia coli (STEC) and their association with diseases remain largely unknown. This study determines the importance of 44 genetic markers for STEC (O157 and non-O157) from human clinical cases and their correlation to disease outcome. STEC isolated from a cattle surveillance program were also included. The virulence genes tested were present in almost all O157:H7 isolates but highly variable in non-O157 STEC isolates. Patient age was a significant determinant of clinical outcome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alberta
  • Animals
  • Cattle
  • Child
  • Child, Preschool
  • Escherichia coli Infections / microbiology*
  • Escherichia coli Infections / veterinary*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Shiga-Toxigenic Escherichia coli / classification
  • Shiga-Toxigenic Escherichia coli / genetics*
  • Shiga-Toxigenic Escherichia coli / isolation & purification*
  • Survival Analysis
  • Virulence Factors / genetics*
  • Young Adult

Substances

  • Virulence Factors