Reply to comment on "An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice"

Yvette I Sheline; Tim West; Kevin Yarasheski; Mateusz S Jasielec; Jane C Hettinger; Danielle L Tripoli; Chengjie Xiong; Christine Frederiksen; Monica V Grzelak; Randall J Bateman; John C Morris; Jin-Moo Lee; John R Cirrito

doi:10.1126/scitranslmed.3010609

Reply to comment on "An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice"

Sci Transl Med. 2014 Dec 24;6(268):268lr4. doi: 10.1126/scitranslmed.3010609.

Authors

Affiliations

¹ Departments of Psychiatry, Radiology, and Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA. sheline@mail.med.upenn.edu.
² C2N Diagnostics LLC, St. Louis, MO 63110, USA.
³ Department of Medicine, Washington University, St. Louis, MO 63110, USA.
⁴ Department of Biostatistics, Washington University, St. Louis, MO 63110, USA.
⁵ Department of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA. Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.
⁶ Department of Biostatistics, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA.
⁷ Department of Surgery, Washington University, St. Louis, MO 63110, USA.
⁸ Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA.
⁹ Department of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA.

Abstract

Possible reasons for why a new study could not replicate our finding that the serotonin reuptake inhibitor citalopram decreased amyloid β concentrations in the cerebrospinal fluid of healthy volunteers.

Publication types

Letter
Comment

MeSH terms

Alzheimer Disease / cerebrospinal fluid*
Alzheimer Disease / genetics*
Amyloid beta-Protein Precursor / cerebrospinal fluid*
Animals
Antidepressive Agents / chemistry*
Citalopram / chemistry*
Female
Humans
Male

Substances

Amyloid beta-Protein Precursor
Antidepressive Agents
Citalopram

Abstract

Publication types

MeSH terms

Substances

Grants and funding