[Advances of lentiviral vectors]

Zhongguo Fei Ai Za Zhi. 2014 Dec;17(12):870-6. doi: 10.3779/j.issn.1009-3419.2014.12.09.
[Article in Chinese]

Abstract

Lentiviral vectors are currently very effective tools in molecular and cell experiment. Lentiviral vector, a kind of retroviral vectors, has a number of unique advantages in target gene transferation, for example, the ability of transfection to the dividing or nondividing cells, its high efficiency of transfection and a capacity of large target gene fragments. This paper describes the sources of lentiviral vectors, molecular characteristics, research progress, etc.

慢病毒载体(lentivirus vector, LV)是目前分子及细胞生物实验中非常有效的工具,在基因转染方面有着许多独特的优势,例如,对细胞是否处于有丝分裂期没有特别的要求,基因转染效率高,可容纳较大基因片段等。本文将就慢病毒载体的来源、分子特征及研究进展等进行综述。

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Genetic Vectors / genetics*
  • Humans
  • Lentivirus / genetics*
  • Transfection / methods*

Grants and funding

本文受天津市高等学校科技发展基金计划项目(No.2006ZD10)资助