Unleashing mesenchymal chemotaxis

Dev Cell. 2014 Dec 22;31(6):669-70. doi: 10.1016/j.devcel.2014.12.005.

Abstract

In this issue of Developmental Cell, Asokan and colleagues (2014) report that the phospholipase Cγ (PLCγ)-diacyl glycerol (DAG) protein kinase Cα (PKCα) signaling axis inhibits actomyosin bundling. This preferentially occurs at the leading edge of chemotactic mesenchymal cells via noncanonical phosphorylation of the regulatory light chain (RLC) of nonmuscle myosin II.

Publication types

  • Comment

MeSH terms

  • Animals
  • Chemotaxis / physiology*
  • Humans
  • Mesoderm / physiology*
  • Myosin Type II / metabolism*
  • Phospholipase C gamma / metabolism*
  • Protein Kinase C-alpha / metabolism*

Substances

  • Protein Kinase C-alpha
  • Phospholipase C gamma
  • Myosin Type II