Surgical Materials: Current Challenges and Nano-enabled Solutions

Nasim Annabi; Ali Tamayol; Su Ryon Shin; Amir M Ghaemmaghami; Nicholas A Peppas; Ali Khademhosseini

doi:10.1016/j.nantod.2014.09.006

Surgical Materials: Current Challenges and Nano-enabled Solutions

Nano Today. 2014 Oct 1;9(5):574-589. doi: 10.1016/j.nantod.2014.09.006.

Authors

Nasim Annabi¹, Ali Tamayol², Su Ryon Shin¹, Amir M Ghaemmaghami³, Nicholas A Peppas⁴, Ali Khademhosseini⁵

Affiliations

¹ Center for Biomaterials Innovation, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
² Center for Biomaterials Innovation, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.
³ Division of Immunology, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, United Kingdom.
⁴ Department of Biomedical Engineering, Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
⁵ Center for Biomaterials Innovation, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA ; Department of Biomedical Engineering, Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA ; Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea ; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia.

Abstract

Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been utilized for generation of a new class of surgical materials with enhanced functionality. In this review, the state of the art in the development of conventional surgical adhesive biomaterials is critically reviewed and their shortcomings are outlined. Recent advancements in generation of nano-enabled surgical materials with their potential future applications are discussed. This review will open new avenues for the innovative development of the next generation of tissue adhesives, hemostats, and sealants with enhanced functionality for various surgical applications.

Abstract

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