Abstract
Phenylboronic acid-rich nanoparticles (PBNPs) were designed as a novel mucoadhesive vaginal drug delivery system. PBNPs effectively adsorbed mucin in vitro and could be easily loaded with the model drug interferon (IFN). Drug release from PBNPs was controlled by the presence of mucin. Neither obvious cytotoxicity nor vaginal histological changes in mice caused by PBNPs or IFN-loaded PBNPs were observed.
Keywords:
Controlled release; Mucin; Mucoadhesion; Nanoparticle; Phenyboronic acid.
Copyright © 2014 Elsevier B.V. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adhesiveness
-
Administration, Intravaginal
-
Animals
-
Boronic Acids / administration & dosage
-
Boronic Acids / chemistry*
-
Boronic Acids / pharmacology
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Drug Delivery Systems*
-
Drug Liberation
-
Female
-
Humans
-
Interferons / administration & dosage
-
Interferons / chemistry
-
Mice, Inbred ICR
-
Mucins / chemistry*
-
Nanoparticles / administration & dosage
-
Nanoparticles / chemistry*
-
Vagina / anatomy & histology
-
Vagina / drug effects
-
Vagina / metabolism
Substances
-
Boronic Acids
-
Mucins
-
Interferons
-
benzeneboronic acid