Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles

Int J Pharm. 2015 Feb 1;479(1):261-4. doi: 10.1016/j.ijpharm.2014.12.011. Epub 2014 Dec 17.

Abstract

Phenylboronic acid-rich nanoparticles (PBNPs) were designed as a novel mucoadhesive vaginal drug delivery system. PBNPs effectively adsorbed mucin in vitro and could be easily loaded with the model drug interferon (IFN). Drug release from PBNPs was controlled by the presence of mucin. Neither obvious cytotoxicity nor vaginal histological changes in mice caused by PBNPs or IFN-loaded PBNPs were observed.

Keywords: Controlled release; Mucin; Mucoadhesion; Nanoparticle; Phenyboronic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesiveness
  • Administration, Intravaginal
  • Animals
  • Boronic Acids / administration & dosage
  • Boronic Acids / chemistry*
  • Boronic Acids / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Drug Delivery Systems*
  • Drug Liberation
  • Female
  • Humans
  • Interferons / administration & dosage
  • Interferons / chemistry
  • Mice, Inbred ICR
  • Mucins / chemistry*
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry*
  • Vagina / anatomy & histology
  • Vagina / drug effects
  • Vagina / metabolism

Substances

  • Boronic Acids
  • Mucins
  • Interferons
  • benzeneboronic acid