Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia

Haematologica. 2015 Mar;100(3):e102-5. doi: 10.3324/haematol.2014.119248. Epub 2014 Dec 19.

Authors

Affiliations

¹ Center for the Biology of the Disease, VIB, Leuven Center for Human Genetics, KU Leuven.
² Department of Pathology UZ Leuven.
³ Laboratory Department of Hematology, AZ St Jan, Brugge.
⁴ Pediatric oncology, UZ Leuven.
⁵ Hematology Department, UZ Leuven, Belgium.
⁶ Center for Human Genetics, KU Leuven.
⁷ Center for the Biology of the Disease, VIB, Leuven Center for Human Genetics, KU Leuven Jan.cools@cme.vib-kuleuven.be.

No abstract available

Keywords: Hedgehog pathway; leukemia; oncogene; signaling.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Animals
Base Sequence
Child
Female
Gene Expression
HEK293 Cells
Humans
Kruppel-Like Transcription Factors / genetics*
Kruppel-Like Transcription Factors / immunology
Male
Mice, Inbred BALB C
Molecular Sequence Data
Mutation
Nerve Tissue Proteins / genetics*
Nerve Tissue Proteins / immunology
Patched Receptors
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / immunology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
Receptors, Cell Surface / genetics*
Receptors, Cell Surface / immunology
Receptors, G-Protein-Coupled / genetics*
Receptors, G-Protein-Coupled / immunology
Signal Transduction
Smoothened Receptor
T-Lymphocytes / immunology
T-Lymphocytes / pathology
T-Lymphocytes / transplantation
Transcription Factors / genetics*
Transcription Factors / immunology
Transduction, Genetic
Zinc Finger Protein GLI1
Zinc Finger Protein Gli3

Substances

GLI1 protein, human
GLI3 protein, human
Kruppel-Like Transcription Factors
Nerve Tissue Proteins
Patched Receptors
Receptors, Cell Surface
Receptors, G-Protein-Coupled
SMO protein, human
Smoothened Receptor
Transcription Factors
Zinc Finger Protein GLI1
Zinc Finger Protein Gli3