Caught in the Act: R-loops are cleaved by structure-specific endonucleases to generate DSBs

Yea-Lih Lin; Philippe Pasero

doi:10.1016/j.molcel.2014.12.011

Caught in the Act: R-loops are cleaved by structure-specific endonucleases to generate DSBs

Mol Cell. 2014 Dec 18;56(6):721-2. doi: 10.1016/j.molcel.2014.12.011.

Authors

Yea-Lih Lin¹, Philippe Pasero²

Affiliations

¹ Institute of Human Genetics, CNRS-UPR 1142, Montpellier, France.
² Institute of Human Genetics, CNRS-UPR 1142, Montpellier, France. Electronic address: ppasero@igh.cnrs.fr.

PMID: 25526530
DOI: 10.1016/j.molcel.2014.12.011

Abstract

Unscheduled RNA-DNA hybrids promote the formation DNA double-strand breaks (DSBs) through poorly characterized mechanism. In this issue, Sollier et al. (2014) show that R-loops are processed by XPF and XPG, two structure-specific endonucleases of the NER pathway, to generate DSBs.

Publication types

Comment

MeSH terms

DNA Repair*
Genomic Instability*
Humans