A Swiss Army knife for CTLs

Peter Friedl; Bettina Weigelin

doi:10.1016/j.immuni.2014.12.008

A Swiss Army knife for CTLs

Immunity. 2014 Dec 18;41(6):873-5. doi: 10.1016/j.immuni.2014.12.008.

Authors

Peter Friedl¹, Bettina Weigelin²

Affiliations

¹ Department of Cell Biology (283), Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands; David H. Koch Center for Applied Research of Genitourinary Cancers, Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Cancer Genomics Centre Netherlands (CGC.nl), Department of Molecular Cancer Research, University Medical Center Utrecht, HP Stratenum 3.217, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands. Electronic address: peter.friedl@radboudumc.nl.
² Department of Cell Biology (283), Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands.

PMID: 25526299
DOI: 10.1016/j.immuni.2014.12.008

Abstract

Granzyme B released by leukocytes cleaves multiple intracellular substrates required for target cell lysis. In this issue of Immunity, Prakash et al. (2014) demonstrate that granzyme B cleaves basement membrane proteins and promotes cytotoxic T cell diapedesis into inflamed tissue.

Publication types

Comment

MeSH terms

Animals
Ectromelia virus / immunology*
Ectromelia, Infectious / immunology*
Granzymes / metabolism*
Killer Cells, Natural / physiology*
T-Lymphocytes, Cytotoxic / physiology*

Substances

Granzymes