Determination of Ethyl Glucuronide in Hair for Detection of Alcohol Consumption in Patients After Liver Transplantation

Ther Drug Monit. 2015 Aug;37(4):539-45. doi: 10.1097/FTD.0000000000000160.

Abstract

Background: Early detection of alcohol misuse in orthotopic liver transplantation recipients is essential to offer patients support and prevent organ damage. Here, ethyl glucuronide, a metabolite of ethanol found in hair (hEtG), was evaluated for detection of alcohol consumption.

Methods: In 104 transplant recipients, 31 with underlying alcoholic liver disease (ALD) and 73 with non-ALD, hEtG was determined in addition to the alcohol markers urine EtG, blood ethanol, methanol, and carbohydrate-deficient transferrin. Results were compared with patients' self-reports in a questionnaire and with physicians' assessments.

Results: By physicians' assessments, 22% of the patients were suspected of consuming alcohol regularly, although only 6% of the patients acknowledged consumption of a moderate or high amount of alcohol. By testing all markers except for hEtG, alcohol consumption was detected in 7% of the patients. When hEtG testing was added to the assessment, consumption was detected in 17% of the patients. Hair-EtG determination alone revealed chronic alcohol consumption of >10 g/d in 15% of the patients. ALD patients had a positive hEtG result significantly more often than non-ALD patients did (32% versus 8%; P = 0.003). Also, the concentration of hEtG was higher in ALD patients (P = 0.049) and revealed alcohol abuse with consumption of >60 g ethanol per day in 23% of ALD and 3% of non-ALD patients. Patients' self-reports and physicians' assessments had a low sensitivity of 27% and 67%, respectively, for detecting regular alcohol intake as indicated by hEtG.

Conclusions: Hair-EtG determination improved the detection of liver transplant patients who used alcohol, and revealed regular alcohol consumption in 32% of ALD and 8% of non-ALD patients.

MeSH terms

  • Alcohol Drinking / metabolism*
  • Biomarkers / analysis
  • Biomarkers / blood
  • Biomarkers / urine
  • Ethanol / blood
  • Female
  • Glucuronates / analysis*
  • Glucuronates / urine
  • Hair / chemistry*
  • Humans
  • Liver Transplantation / methods*
  • Male
  • Methanol / blood
  • Middle Aged
  • Predictive Value of Tests
  • Substance Abuse Detection / methods*
  • Transferrin / analogs & derivatives
  • Transferrin / metabolism

Substances

  • Biomarkers
  • Glucuronates
  • Transferrin
  • carbohydrate-deficient transferrin
  • ethyl glucuronide
  • Ethanol
  • Methanol