Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus

J Nat Prod. 2015 Jan 23;78(1):2-9. doi: 10.1021/np5004092. Epub 2014 Dec 19.

Abstract

The chemical composition and biofilm regulation of 15 metabolites from Teucrium polium are reported. Compounds were isolated from a CH2Cl2-MeOH extract of the aerial parts of the plant and included iridoid and phenylethanol glycosides and a monoterpenoid, together with nine known compounds. The structures were elucidated based on standard spectroscopic (UV, (1)H and (13)C NMR), 2D NMR ((1)H-(1)H COSY, HMQC, HMBC, and NOESY), and/or LC-ESIMS/MS data analyses. Inhibition of the biofilm-forming strain Staphylococcus aureus was observed with exposure to compounds 7 and 8.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biofilms / drug effects*
  • Egypt
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology*
  • Iridoid Glycosides / chemistry
  • Iridoid Glycosides / isolation & purification*
  • Iridoid Glycosides / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Monoterpenes / chemistry
  • Monoterpenes / isolation & purification*
  • Monoterpenes / pharmacology*
  • Nuclear Magnetic Resonance, Biomolecular
  • Phenylethyl Alcohol / chemistry
  • Phenylethyl Alcohol / isolation & purification*
  • Phenylethyl Alcohol / pharmacology*
  • Staphylococcus aureus / drug effects*
  • Teucrium / chemistry*

Substances

  • Flavonoids
  • Iridoid Glycosides
  • Monoterpenes
  • Phenylethyl Alcohol