Exposure to extremely low-frequency magnetic field affects biofilm formation by cystic fibrosis pathogens

Future Microbiol. 2014;9(12):1303-17. doi: 10.2217/fmb.14.96.

Abstract

Aims: To evaluate the in vitro effects of extremely low-frequency magnetic field (ELF-MF) on growth and biofilm formation by Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia and Stenotrophomonas maltophilia strains from cystic fibrosis patients.

Materials & methods: The motion of selected ions (Fe, Ca, Cu, Zn, Mg, K, Na) was stimulated by the ion resonance effect, then influence on growth and biofilm formation/viability was assessed by spectrophotometry or viability count.

Results: Generally, exposure to ELF-MF significantly increased bacterial growth and affected both biofilm formation and viability, although with differences with regard to ions and species considered.

Conclusion: Exposure to ELF-MF represents a possible new approach for treatment of biofilm-associated cystic fibrosis lung infections.

Keywords: Burkholderia cepacia; Pseudomonas aeruginosa; Staphylococcus aureus; Stenotrophomonas maltophilia; biofilm formation; cystic fibrosis; extremely low-frequency magnetic field; lung infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biofilms / growth & development*
  • Burkholderia cepacia / growth & development
  • Burkholderia cepacia / physiology
  • Cystic Fibrosis / microbiology*
  • Gram-Negative Bacteria / growth & development
  • Gram-Negative Bacteria / physiology*
  • Humans
  • Ion Channels / metabolism
  • Magnetic Fields*
  • Microbial Viability
  • Pseudomonas aeruginosa / growth & development
  • Pseudomonas aeruginosa / physiology
  • Spectrophotometry, Ultraviolet
  • Staphylococcus aureus / growth & development
  • Staphylococcus aureus / physiology*
  • Stenotrophomonas maltophilia / growth & development
  • Stenotrophomonas maltophilia / physiology

Substances

  • Ion Channels