Genetic analysis of the 'uveal melanoma' C918 cell line reveals atypical BRAF and common KRAS mutations and single tandem repeat profile identical to the cutaneous melanoma C8161 cell line

Pigment Cell Melanoma Res. 2015 May;28(3):357-9. doi: 10.1111/pcmr.12345. Epub 2015 Mar 23.

Authors

Xiaoxing Yu¹, Grazia Ambrosini, Jason Roszik, Agda Karina Eterovic, Katherine Stempke-Hale, Elisabeth A Seftor, Chandrani Chattopadhyay, Elizabeth Grimm, Richard D Carvajal, Mary J C Hendrix, F Stephen Hodi, Gary K Schwartz, Scott E Woodman

Affiliation

¹ Department of Melanoma Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA; Systems Biology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.

PMID: 25515650
DOI: 10.1111/pcmr.12345

No abstract available

Publication types

Letter

MeSH terms

Cell Line, Tumor
Humans
Melanoma / genetics*
Microsatellite Repeats / genetics
Mutation / genetics*
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins B-raf / genetics*
Proto-Oncogene Proteins p21(ras)
Repetitive Sequences, Nucleic Acid / genetics*
Uveal Neoplasms / genetics*
ras Proteins / genetics*

Substances

KRAS protein, human
Proto-Oncogene Proteins
BRAF protein, human
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)
ras Proteins

Supplementary concepts

Uveal melanoma