Two new coumarins from Talaromyces flavus

Molecules. 2014 Dec 12;19(12):20880-7. doi: 10.3390/molecules191220880.

Abstract

Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher's method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh2(OCOCF3)4] complex. Compounds 1 and 2 were evaluated for their anti-Aβ42 aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ42 aggregation activity, and this is the first report on the Aβ42 inhibitory aggregation activity of coumarins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / chemistry
  • Aspergillus niger / drug effects
  • Candida albicans / drug effects
  • Cell Line, Tumor
  • Cell Survival
  • Coumarins / chemistry*
  • Coumarins / isolation & purification
  • Coumarins / pharmacology
  • Escherichia coli / drug effects
  • Humans
  • Inhibitory Concentration 50
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Peptide Fragments / chemistry
  • Protein Aggregates
  • Staphylococcus aureus / drug effects
  • Talaromyces / chemistry*

Substances

  • Amyloid beta-Peptides
  • Coumarins
  • Peptide Fragments
  • Protein Aggregates
  • amyloid beta-protein (1-42)
  • talacoumarin A
  • talacoumarin B