Abstract
A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Cyclization
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ErbB Receptors / antagonists & inhibitors*
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Iodides / chemistry
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Lactones / chemical synthesis*
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Lactones / chemistry
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Molecular Conformation
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Molecular Structure
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Samarium / chemistry
Substances
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Iodides
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Lactones
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clavilactone B
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Samarium
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ErbB Receptors
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samarium diiodide