Circumventing failed antiviral immunity in chronic hepatitis B virus infection: triggering virus-specific or innate-like T cell response?

Sarene Koh; Antonio Bertoletti

doi:10.1007/s00430-014-0377-7

Circumventing failed antiviral immunity in chronic hepatitis B virus infection: triggering virus-specific or innate-like T cell response?

Med Microbiol Immunol. 2015 Feb;204(1):87-94. doi: 10.1007/s00430-014-0377-7. Epub 2014 Dec 16.

Authors

Sarene Koh¹, Antonio Bertoletti

Affiliation

¹ Viral Hepatitis Unit, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, sarene_koh@sics.a-star.edu.sg.

PMID: 25511870
DOI: 10.1007/s00430-014-0377-7

Abstract

Therapeutic vaccination for the treatment of chronic hepatitis B has thus far been unsatisfactory. In this review, we discuss potential new therapeutic vaccination strategies and other immunotherapeutic approaches that aim to achieve efficient restoration of HBV immunity in chronically infected patients.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptive Immunity*
Hepatitis B virus / immunology*
Hepatitis B, Chronic / immunology*
Hepatitis B, Chronic / therapy*
Humans
Immunity, Innate*
Immunotherapy / methods*
T-Lymphocytes / immunology*