What do we know about ribosomal RNA methylation in Escherichia coli?

O V Sergeeva; A A Bogdanov; P V Sergiev

doi:10.1016/j.biochi.2014.11.019

What do we know about ribosomal RNA methylation in Escherichia coli?

Biochimie. 2015 Oct:117:110-8. doi: 10.1016/j.biochi.2014.11.019. Epub 2014 Dec 13.

Authors

O V Sergeeva¹, A A Bogdanov², P V Sergiev²

Affiliations

¹ Chemistry Department, Lomonosov Moscow State University, Moscow 119991, Russia; Skolkovo Institute of Science and Technology, Skolkovo, Moscow 143025, Russia. Electronic address: olga.sergeeva.v@gmail.com.
² Chemistry Department, Lomonosov Moscow State University, Moscow 119991, Russia; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119991, Russia.

PMID: 25511423
DOI: 10.1016/j.biochi.2014.11.019

Abstract

A ribosome is a ribonucleoprotein that performs the synthesis of proteins. Ribosomal RNA of all organisms includes a number of modified nucleotides, such as base or ribose methylated and pseudouridines. Methylated nucleotides are highly conserved in bacteria and some even universally. In this review we discuss available data on a set of modification sites in the most studied bacteria, Escherichia coli. While most rRNA modification enzymes are known for this organism, the function of the modified nucleotides is rarely identified.

Keywords: Escherichia coli; Modification; RNA methyltransferase; Ribosome; Ribosome assembly; rRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Escherichia coli / genetics*
Escherichia coli / metabolism
Escherichia coli Proteins / chemistry
Escherichia coli Proteins / metabolism
Methylation
Methyltransferases / chemistry
Methyltransferases / metabolism
Models, Molecular
Nucleic Acid Conformation
Protein Binding
RNA, Bacterial / chemistry
RNA, Bacterial / genetics*
RNA, Bacterial / metabolism
RNA, Messenger / chemistry
RNA, Messenger / genetics
RNA, Messenger / metabolism
RNA, Ribosomal / chemistry
RNA, Ribosomal / genetics*
RNA, Ribosomal / metabolism
Ribosomes / genetics*
Ribosomes / metabolism

Substances

Escherichia coli Proteins
RNA, Bacterial
RNA, Messenger
RNA, Ribosomal
Methyltransferases
RsmD protein, E coli