In utero preeclampsia exposure, milk intake and pubertal development

Jeremy Michals Schraw; Bjorn Øgland; Yong Quan Dong; Stein Tore Nilsen; Michele R Forman

doi:10.1016/j.reprotox.2014.12.004

In utero preeclampsia exposure, milk intake and pubertal development

Reprod Toxicol. 2015 Jul:54:19-25. doi: 10.1016/j.reprotox.2014.12.004. Epub 2014 Dec 12.

Authors

Jeremy Michals Schraw¹, Bjorn Øgland², Yong Quan Dong³, Stein Tore Nilsen⁴, Michele R Forman⁵

Affiliations

¹ Department of Nutritional Sciences, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, Austin, TX 78723, United States. Electronic address: schrawj@utexas.edu.
² Intensive Care Unit, Oslo University Hospital, Box 4950, Nydalen, 0424 Oslo, Norway. Electronic address: bjooeg@ous-hf.no.
³ Department of Nutritional Sciences, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, Austin, TX 78723, United States. Electronic address: kanedong@austin.utexas.edu.
⁴ Stavanger University Hospital, Postboks 8100, 4068 Stavanger, Norge, Norway. Electronic address: stein.tore.nilsen@sus.no.
⁵ Department of Nutritional Sciences, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, Austin, TX 78723, United States. Electronic address: mforman@austin.utexas.edu.

PMID: 25511106
DOI: 10.1016/j.reprotox.2014.12.004

Abstract

Cord blood insulin-like growth factor-1 (IGF-1) concentrations are lower in preeclamptic (PE) than normotensive (NT) pregnancies. PE offspring have increased risk of cardiovascular disease and decreased risk of some cancers including breast. We examined the effects of PE exposure in utero, infant feeding and childhood diet at 3-5 years on IGF-1 and breast development in 194 female offspring who were followed from birth until follow-ups at 10.8 and 12.9 years. Diet was not associated with serum IGF-1 levels at 10.8 years. PE exposure was associated with reduced odds of thelarche at 10.8 years only among exclusively breastfed girls. Milk, butter and ice cream consumption at 3-5 years was inversely related to the OR of breast development at 10.8 years. Child's weight and maternal overweight were positively associated with breast development at 10.8 years; child's height and weight were positively associated with breast development at 12.9 years.

Keywords: Breast development; Childhood diet; Dairy consumption; Developmental programming; Infant feeding; Preeclampsia; Puberty.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Age Factors
Animals
Biomarkers / blood
Body Height
Body Weight
Breast Feeding
Butter
Case-Control Studies
Chi-Square Distribution
Child
Child Development*
Child Nutritional Physiological Phenomena*
Child, Preschool
Diet
Dietary Fats / administration & dosage
Dietary Proteins / administration & dosage
Feeding Behavior
Female
Humans
Ice Cream
Infant
Infant, Newborn
Insulin-Like Growth Factor I / metabolism
Linear Models
Logistic Models
Mammary Glands, Human / growth & development*
Milk*
Nutritional Status
Odds Ratio
Pre-Eclampsia / blood
Pre-Eclampsia / physiopathology*
Pregnancy
Prenatal Exposure Delayed Effects*
Prospective Studies
Puberty*
Risk Factors

Substances

Biomarkers
Dietary Fats
Dietary Proteins
IGF1 protein, human
Insulin-Like Growth Factor I
Butter