Abstract
In vivo detection of cancer at an early-stage, i.e. smaller than 2 mm, is a challenge in biomedicine. In this work target labeling of an early-stage tumor spheroid (∼500 μm) is realized for the first time in a chick embryo chorioallantoic membrane (CAM) model with monoclonal antibody functionalized upconversion nanoparticles (UCNPs-mAb).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells
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Animals
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Antibodies, Monoclonal / chemistry
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Antibodies, Monoclonal / immunology
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Cell Survival / drug effects
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Chick Embryo
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Chickens
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Chorioallantoic Membrane / drug effects
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Chorioallantoic Membrane / physiology
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Fluorides / chemistry
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Humans
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MCF-7 Cells
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Mice
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Microscopy, Confocal
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Models, Biological*
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Nanoparticles / chemistry*
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Nanoparticles / metabolism
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Nanoparticles / toxicity
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Neoplasm Staging
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Neoplasms / pathology
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Yttrium / chemistry
Substances
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Antibodies, Monoclonal
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sodium yttriumtetrafluoride
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Yttrium
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Fluorides