Access to large cyclic peptides by a one-pot two-peptide segment ligation/cyclization process

Org Lett. 2015 Jan 2;17(1):130-3. doi: 10.1021/ol503359w. Epub 2014 Dec 15.

Abstract

The use of the N-acetoacetyl protecting group for N-terminal cysteine residue enabled creation of an efficient and mild one-pot native chemical ligation/SEA ligation sequence giving access to large cyclic peptides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclization
  • Cysteine / chemistry
  • Ligation
  • Molecular Structure
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry
  • Thiazolidines / chemistry

Substances

  • Peptides, Cyclic
  • Thiazolidines
  • Cysteine