Abstract
The use of the N-acetoacetyl protecting group for N-terminal cysteine residue enabled creation of an efficient and mild one-pot native chemical ligation/SEA ligation sequence giving access to large cyclic peptides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cyclization
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Cysteine / chemistry
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Ligation
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Molecular Structure
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Peptides, Cyclic / chemical synthesis*
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Peptides, Cyclic / chemistry
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Thiazolidines / chemistry
Substances
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Peptides, Cyclic
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Thiazolidines
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Cysteine