The ubiquitin modification has various functions in the host innate immune system in response to the bacterial infection. To counteract the host immunity, Salmonella can specifically target ubiquitin pathways by its effector proteins. In this review, we describe the multiple facets of ubiquitin function during infection with Salmonella enterica Typhimurium and hypothesize how these studies on the host-pathogen interactions can help to understand the general function of the ubiquitination pathway in the host cell.
Keywords: E3 ligases; Salmonella enterica Typhimurium; Salmonella-containing vacuole; autophagy; deubiquitinases; innate immune response; type III secretion system; ubiquitin.