A free-blockage controlled release system based on the hydrophobic/hydrophilic conversion of mesoporous silica nanopores

Chemistry. 2015 Feb 2;21(6):2680-5. doi: 10.1002/chem.201405222. Epub 2014 Dec 11.

Abstract

A pH-responsive free-blockage release system was achieved through controlling the hydrophobic/hydrophilic conversion of mesoporous silica nanopores. This system further presented pulsatile release with changing pH values between 4.0 and 7.0 for several cycles. This free-blockage release system could also release antitumor agents to induce cell death after infecting tumor cells and could have the ability of continuous infection to tumor cells with high drug-delivery efficiency and few side effects.

Keywords: controlled release; drug delivery; hydrophobic/hydrophilic effects; mesoporous materials; silica.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / toxicity
  • Cell Survival / drug effects
  • Delayed-Action Preparations
  • Drug Carriers / chemistry*
  • Epirubicin / chemistry
  • Epirubicin / toxicity
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Hydrophobic and Hydrophilic Interactions
  • Nanoparticles / chemistry
  • Nanopores*
  • Porosity
  • Silicon Dioxide / chemistry*

Substances

  • Antineoplastic Agents
  • Delayed-Action Preparations
  • Drug Carriers
  • Epirubicin
  • Silicon Dioxide