PSCA and MUC1 gene polymorphisms are associated with gastric cancer and pre-malignant gastric conditions [corrected]

Juozas Kupcinskas; Thomas Wex; Alexander Link; Ruta Bartuseviciute; Milda Dedelaite; Gintare Kevalaite; Marcis Leja; Jurgita Skieceviciene; Gediminas Kiudelis; Laimas Jonaitis; Limas Kupcinskas; Peter Malfertheiner

PSCA and MUC1 gene polymorphisms are associated with gastric cancer and pre-malignant gastric conditions [corrected]

Anticancer Res. 2014 Dec;34(12):7167-75.

Affiliations

¹ Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
² Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany Medical Laboratory for Clinical Chemistry, Microbiology and Infectious Diseases, Department of Molecular Genetics, Otto von Guericke University, Magdeburg, Germany.
³ Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany.
⁴ Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
⁵ Faculty of Medicine, University of Latvia, Riga, Latvia Digestive Diseases Center GASTRO, Riga, Latvia Riga East University Hospital, Riga, Latvia.
⁶ Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
⁷ Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania l.kupcinskas@gmail.com.

PMID: 25503145

Abstract

Background/aim: Genome-wide association studies revealed a link between gastric cancer (GC) and single nucleotide polymorphisms (SNPs) of prostate stem cell antigen (PSCA), phospholipase C epsilon-1 (PLCE1) and mucin-1 (MUC1) genes. Herein, we aimed to evaluate associations between PSCA (C>T, rs2294008; G>A, rs2976392), MUC1 (C>T, rs4072037) and PLCE1 (A>G, rs2274223) SNPs and GC or high-risk gastritis (HRAG).

Materials and methods: Using TaqMan system, SNPs were genotyped in 252 patients with GC, 136 patients with HRAG and 246 controls.

Results: PSCA rs2294008 allele T was associated with risk of GC (odds ratio (OR)=1.88, p<0.001) and HRAG (OR=1.49, p=0.009). Allele A of PSCA rs2976392 was associated with development of GC (OR=1.88, p<0.001) and HRAG (OR=1.56, p<0.01). MUC1 rs4072037 allele G was protective against development of GC (OR=0.64, p=0.0005), while no differences were found for PLCE1 rs2274223.

Conclusion: Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.

Keywords: MUC1; PLCE1; PSCA; SNP; gastric cancer; gastritis; gene polymorphism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Antigens, Neoplasm / genetics*
Female
GPI-Linked Proteins / genetics
Gastritis / genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Mucin-1 / genetics*
Neoplasm Proteins / genetics*
Phosphoinositide Phospholipase C / genetics*
Polymorphism, Single Nucleotide
Precancerous Conditions / genetics*
Stomach Neoplasms / genetics*
White People / genetics

Substances

Antigens, Neoplasm
GPI-Linked Proteins
MUC1 protein, human
Mucin-1
Neoplasm Proteins
PSCA protein, human
Phosphoinositide Phospholipase C
phospholipase C epsilon