Amide-triazole isosteric substitution for tuning self-assembly and incorporating new functions into soft supramolecular materials

Chem Commun (Camb). 2015 Mar 28;51(25):5294-7. doi: 10.1039/c4cc08593k.

Abstract

The proof-of-concept for the modular synthesis of new functional soft gel materials based on amide-triazole isosteric replacement has been demonstrated. A coassembly approach of isosteric amino acid-based hydrogelators was fruitfully applied for fine-tuning the release of entrapped drugs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Amino Acids / chemistry
  • Hydrogels / chemical synthesis*
  • Hydrogels / chemistry
  • Macromolecular Substances / chemical synthesis
  • Macromolecular Substances / chemistry
  • Molecular Conformation
  • Stereoisomerism
  • Triazoles / chemistry*

Substances

  • Amides
  • Amino Acids
  • Hydrogels
  • Macromolecular Substances
  • Triazoles