Coupling of carboxylic acids with internal alkynes by supported ruthenium catalysts: direct and selective syntheses of multi-substituted phthalide derivatives

Hiroki Miura; Kentaro Tsutsui; Kenji Wada; Tetsuya Shishido

doi:10.1039/c4cc08461f

Coupling of carboxylic acids with internal alkynes by supported ruthenium catalysts: direct and selective syntheses of multi-substituted phthalide derivatives

Chem Commun (Camb). 2015 Jan 31;51(9):1654-7. doi: 10.1039/c4cc08461f.

Authors

Hiroki Miura¹, Kentaro Tsutsui, Kenji Wada, Tetsuya Shishido

Affiliation

¹ Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo 192-0397, Japan. shishido-tetsuya@tmu.ac.jp.

PMID: 25501995
DOI: 10.1039/c4cc08461f

Abstract

Supported ruthenium catalysts promote coupling of various kinds of aromatic carboxylic acids with internal alkynes, giving the corresponding multi-substituted phthalide derivatives in high yields. The supported Ru catalyst can be recycled at least five times with no loss of activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry*
Benzofurans / chemical synthesis
Benzofurans / chemistry*
Carboxylic Acids / chemistry*
Catalysis
Molecular Structure
Ruthenium / chemistry*

Substances

Alkynes
Benzofurans
Carboxylic Acids
Ruthenium
phthalide