Are low ultraviolet B and vitamin D associated with higher incidence of multiple myeloma?

Sharif B Mohr; Edward D Gorham; Cedric F Garland; William B Grant; Frank C Garland; Raphael E Cuomo

doi:10.1016/j.jsbmb.2014.12.005

Are low ultraviolet B and vitamin D associated with higher incidence of multiple myeloma?

J Steroid Biochem Mol Biol. 2015 Apr:148:245-52. doi: 10.1016/j.jsbmb.2014.12.005. Epub 2014 Dec 10.

Authors

Sharif B Mohr¹, Edward D Gorham¹, Cedric F Garland², William B Grant³, Frank C Garland¹, Raphael E Cuomo⁴

Affiliations

¹ Deartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States; Naval Health Research Center, San Diego, CA, United States.
² Deartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States.
³ Sunlight, Nutrition, and Health Research Center, San Francisco, CA, United States.
⁴ Deartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States; Graduate School of Public Health, San Diego State University, San Diego, CA, United States. Electronic address: raphael.e.cuomo@gmail.com.

PMID: 25500072
DOI: 10.1016/j.jsbmb.2014.12.005

Abstract

The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, and incidence rates of multiple myeloma.Methods Associations of latitude and UVB irradiance with age-standardized incidence rates of multiple myeloma were analyzed for 175 countries while controlling for sex-specific obesity prevalence, cigarette consumption, and alcohol consumption using multiple linear regression.Results Incidence rates of multiple myeloma were greater at higher latitudes (R(2) for latitude for males=0.31, p<0.0001; females R(2)=0.27, p<0.0001). In regression models for males (R(2)=0.62, p<0.0001) and females (R(2)=0.51, p<0.0001), UVB irradiance was independently inversely associated with incidence rates.Conclusions Age-adjusted incidence rates of multiple myeloma were higher in countries with lower solar UVB irradiance. Further investigation is warranted in individuals of the association of prediagnostic serum 25(OH)D with risk.

Keywords: Alcohol; Cigarettes; Incidence; International comparisons; Multiple regression; Myeloma; Ultraviolet rays; Vitamin D.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Female
Humans
Incidence
Male
Multiple Myeloma / epidemiology*
Multiple Myeloma / etiology*
Risk Factors
Sunlight / adverse effects*
Ultraviolet Rays / adverse effects*
Vitamin D Deficiency / complications*