Severe fever with thrombocytopenia syndrome and its pathogen SFTSV

Xiao-Ying Lei; Miao-Miao Liu; Xue-Jie Yu

doi:10.1016/j.micinf.2014.12.002

Severe fever with thrombocytopenia syndrome and its pathogen SFTSV

Microbes Infect. 2015 Feb;17(2):149-54. doi: 10.1016/j.micinf.2014.12.002. Epub 2014 Dec 11.

Authors

Xiao-Ying Lei¹, Miao-Miao Liu¹, Xue-Jie Yu²

Affiliations

¹ School of Public Health, Shandong University, Jinan 250012, China.
² School of Public Health, Shandong University, Jinan 250012, China; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA. Electronic address: yuxuejie@sdu.edu.cn.

PMID: 25498868
DOI: 10.1016/j.micinf.2014.12.002

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in East Asia with case fatality up to 50%. SFTS is caused by SFTSV, a tick borne bunyavirus. In endemic area in China 1%-3% population was infected with SFTSV, but age is critical risk factor for hospitalization and death of SFTS patients.

Keywords: Bunyavirus; Hemorrhagic fever; Phlebovirus; SFTSV; Severe fever with thrombocytopenia syndrome.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Arthropod Vectors
Bunyaviridae Infections / complications
Bunyaviridae Infections / epidemiology
Bunyaviridae Infections / virology*
China / epidemiology
Disease Models, Animal
Hemorrhagic Fevers, Viral / complications
Hemorrhagic Fevers, Viral / epidemiology
Hemorrhagic Fevers, Viral / virology*
Humans
Phlebovirus / genetics*
Phlebovirus / pathogenicity*
Phlebovirus / physiology
Syndrome
Thrombocytopenia / complications
Thrombocytopenia / epidemiology
Thrombocytopenia / virology*
Virus Replication