Recent progress on DNA based walkers

Jing Pan; Feiran Li; Tae-Gon Cha; Haorong Chen; Jong Hyun Choi

doi:10.1016/j.copbio.2014.11.017

Recent progress on DNA based walkers

Curr Opin Biotechnol. 2015 Aug:34:56-64. doi: 10.1016/j.copbio.2014.11.017. Epub 2014 Dec 8.

Authors

Jing Pan¹, Feiran Li¹, Tae-Gon Cha¹, Haorong Chen¹, Jong Hyun Choi²

Affiliations

¹ School of Mechanical Engineering, Purdue University, Mechanical Engineering Building, 585 Purdue Mall, West Lafayette, IN 47907, USA.
² School of Mechanical Engineering, Purdue University, Mechanical Engineering Building, 585 Purdue Mall, West Lafayette, IN 47907, USA. Electronic address: jchoi@purdue.edu.

PMID: 25498478
DOI: 10.1016/j.copbio.2014.11.017

Abstract

DNA based synthetic molecular walkers are reminiscent of biological protein motors. They are powered by hybridization with fuel strands, environment induced conformational transitions, and covalent chemistry of oligonucleotides. Recent developments in experimental techniques enable direct observation of individual walkers with high temporal and spatial resolution. The functionalities of state-of-the-art DNA walker systems can thus be analyzed for various applications. Herein we review recent progress on DNA walker principles and characterization methods, and evaluate various aspects of their functions for future applications.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

DNA / chemistry*
DNA / genetics
Humans
Nucleic Acid Hybridization
Proteins / genetics
RNA / chemistry
RNA / genetics
Reproducibility of Results

Substances

Proteins
RNA
DNA