Pathogens' exploitation of the intestinal food web

Tu Anh Pham N; Trevor D Lawley

doi:10.1016/j.chom.2014.11.012

Pathogens' exploitation of the intestinal food web

Cell Host Microbe. 2014 Dec 10;16(6):703-5. doi: 10.1016/j.chom.2014.11.012.

Authors

Tu Anh Pham N¹, Trevor D Lawley²

Affiliations

¹ Host-Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute, Cambridge, UK.
² Host-Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute, Cambridge, UK. Electronic address: tl2@sanger.ac.uk.

PMID: 25498340
DOI: 10.1016/j.chom.2014.11.012

Abstract

Competition for nutrients is a key factor controlling pathogen colonization within the gastrointestinal tract. In this issue, Ferreyra et al. (2014) and Curtis et al. (2014) show that diverse enteric pathogens can exploit a metabolic byproduct from the commensal microbiota, succinate, to enhance their own virulence expression and proliferation.

Publication types

Comment

MeSH terms

Animals
Anti-Bacterial Agents / administration & dosage*
Bacteroides / physiology*
Clostridioides difficile / physiology*
Clostridium Infections / drug therapy*
Enterobacteriaceae Infections / metabolism*
Enterobacteriaceae Infections / microbiology*
Female
Gastrointestinal Tract / metabolism*
Gastrointestinal Tract / microbiology*
Humans
Male
Microbiota*
Succinic Acid / metabolism*

Substances

Anti-Bacterial Agents
Succinic Acid