Polymorphic expression of CYP2C19 and CYP2D6 in the developing and adult human brain causing variability in cognition, risk for depression and suicide: the search for the endogenous substrates

Pharmacogenomics. 2014;15(15):1841-4. doi: 10.2217/pgs.14.151.

Authors

Magnus Ingelman-Sundberg¹, Anna Persson, Marin M Jukic

Affiliation

¹ Department of Physiology & Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-17177 Stockholm, Sweden.

PMID: 25495406
DOI: 10.2217/pgs.14.151

No abstract available

Keywords: GABA receptors; depression; endocannabinoids; gene duplication; serotonin; ultrarapid metabolizer.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Brain / growth & development*
Brain / physiopathology
Cognition Disorders / genetics
Cognition Disorders / pathology
Cytochrome P-450 CYP2C19 / biosynthesis
Cytochrome P-450 CYP2C19 / genetics*
Cytochrome P-450 CYP2D6 / biosynthesis
Cytochrome P-450 CYP2D6 / genetics*
Depression / genetics
Depression / pathology
Gene Expression Regulation, Developmental
Humans
Suicide

Substances

CYP2C19 protein, human
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2D6