Abstract
A dual stimuli-responsive multi-drug delivery system was developed for "cancer cocktail therapy". Upon UV irradiation, microcapsules could rapidly release the small-molecule drugs, and thereafter the macromolecular drugs would be released in the presence of MMP in the tumor cells. This system will find great potential as a novel chemotherapeutic combination for cancer treatment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / administration & dosage
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Cell Line, Tumor
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Delayed-Action Preparations
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Dextrans / administration & dosage
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Dextrans / chemistry
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Dextrans / radiation effects
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Drug Delivery Systems*
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Endocytosis
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Fluorescein-5-isothiocyanate / administration & dosage
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Fluorescein-5-isothiocyanate / chemistry
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Fluorescein-5-isothiocyanate / radiation effects
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Humans
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Matrix Metalloproteinases / chemistry
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Matrix Metalloproteinases / metabolism*
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Matrix Metalloproteinases / radiation effects
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Polymers / chemistry
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Rhodamines / administration & dosage
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Rhodamines / chemistry
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Rhodamines / radiation effects
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Ultraviolet Rays*
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alpha-Cyclodextrins / administration & dosage
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alpha-Cyclodextrins / chemistry
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alpha-Cyclodextrins / radiation effects
Substances
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Antineoplastic Agents
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Delayed-Action Preparations
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Dextrans
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Polymers
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Rhodamines
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alpha-Cyclodextrins
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Matrix Metalloproteinases
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Fluorescein-5-isothiocyanate
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rhodamine B