A curcumin-based TPA four-branched copper(II) complex probe for in vivo early tumor detection

Zongxin Pi; Jiafeng Wang; Bo Jiang; Gang Cheng; Shuangsheng Zhou

doi:10.1016/j.msec.2014.10.061

A curcumin-based TPA four-branched copper(II) complex probe for in vivo early tumor detection

Mater Sci Eng C Mater Biol Appl. 2015 Jan:46:565-71. doi: 10.1016/j.msec.2014.10.061. Epub 2014 Oct 24.

Authors

Zongxin Pi¹, Jiafeng Wang², Bo Jiang², Gang Cheng¹, Shuangsheng Zhou³

Affiliations

¹ Department of Chemical and Chemical Engineering, Hefei Normal University, Hefei 230001, PR China.
² Department of Pharmacy, Anhui University of Chinese Medicine, Hefei 230038, PR China.
³ Department of Pharmacy, Anhui University of Chinese Medicine, Hefei 230038, PR China; Center of Modern Experimental Technology, Anhui University, Hefei 230038, PR China. Electronic address: zshuangsheng@126.com.

PMID: 25492022
DOI: 10.1016/j.msec.2014.10.061

Abstract

A multibranched Cu(II) complex CuL2 curcumin-based was synthesized and characterized by single-crystal X-ray diffraction analysis. The photophysical properties of the complex have been investigated both experimentally and theoretically. The results show that the target complex exhibits higher quantum yield and larger two-photon absorption (TPA) cross-section in the near infrared (NIR) region compared with its free ligand. The cell imaging studies in vitro and in vivo reveal that the complex shows good photostability and excellent tumor targeting capability to tested cancerous cells, which can be potentially used for early tumor detection.

Keywords: Cell imaging; Crystal structure; Early tumor detection; Multi-branched Cu(II) complex; Photophysical property.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Curcumin / chemistry*
Early Diagnosis*
Humans
MCF-7 Cells
Mice
Microscopy, Electron, Scanning
Neoplasms / diagnosis*
Spectroscopy, Near-Infrared

Substances

Curcumin