Current perspectives on reflux laryngitis

Clin J Gastroenterol. 2014 Dec;7(6):471-5. doi: 10.1007/s12328-014-0535-x. Epub 2014 Nov 1.

Abstract

Laryngopharyngeal reflux (LPR) is an extraesophageal manifestation of gastroesophageal reflux disease (GERD). With the increase of GERD patients, the importance of LPR is acknowledged widely. However, the pathophysiology of LPR is not understood completely and the diagnostic criteria for LPR remain controversial. Unfortunately, a gold standard diagnostic test for reflux laryngitis is not available. Recently, an experimental animal model for reflux laryngitis was developed to investigate the pathophysiology of reflux laryngitis. An empirical trial of lifestyle modification and proton pump inhibitor therapy is a reasonable approach for LPR symptoms. Alternatives after failure with aggressive medical treatment are limited and multichannel intraluminal impedance and pH monitoring is currently the best alternative to detect nonacid reflux. Additional prospective and evidence-based research is anticipated.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Esophageal pH Monitoring
  • Fundoplication
  • Health Behavior
  • Humans
  • Laryngopharyngeal Reflux* / diagnosis
  • Laryngopharyngeal Reflux* / physiopathology
  • Laryngopharyngeal Reflux* / therapy
  • Laryngoscopy
  • Life Style
  • Male
  • Pepsin A / analysis
  • Proton Pump Inhibitors / therapeutic use

Substances

  • Proton Pump Inhibitors
  • Pepsin A