Electrospun TiO₂ nanofibers decorated Ti substrate for biomedical application

Mater Sci Eng C Mater Biol Appl. 2014 Dec:45:56-63. doi: 10.1016/j.msec.2014.08.055. Epub 2014 Sep 6.

Abstract

Various TiO2 nanofibers on Ti surface have been fabricated via electrospinning and calcination. Due to different elaboration conditions the electrospun fibers have different surface feature morphologies, characterized by scanning electronic microscopy, surface roughness, and contact angle measurements. The results have indicated that the average sample diameters are between 32 and 44 nm, roughness between 61 and 416 nm, and all samples are hydrophilic. As biological evaluation, cell culture with MG63 cell line originally derived from a human osteosarcoma was performed and correlation between nanofibers elaboration, properties and cell response was established. The cell adherence and growth are more evident on Ti samples with more aligned fibers, higher roughness and strong hydrophilic character and such fibers have been elaborated with a high speed rotating cylinder collector, confirming the idea that nanostructure elaboration conditions guide the cells' growth.

Keywords: Cell growth; Electrospinning; Surface modification; TiO(2) nanofiber.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actin Cytoskeleton / chemistry
  • Actin Cytoskeleton / metabolism
  • Cell Adhesion / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Humans
  • Microscopy, Atomic Force
  • Microscopy, Electron, Scanning
  • Nanofibers / chemistry*
  • Nanofibers / toxicity
  • Nanofibers / ultrastructure
  • Surface Properties
  • Titanium / chemistry*

Substances

  • titanium dioxide
  • Titanium