Objective: To investigate the expressions of serine-threonine kinase (Akt)/mammalian target of rapamycin (mTOR)/p70 S6K in oral squamous cell carcinoma (OSCC) and provide references for early diagnosis and prognosis evalua- tion of OSCC.
Methods: A total of 51 cases of OSCC, 10 cases of paracancerous mucosa, and 10 cases of normal oral mucosa were collected. The expressions of Akt/mTOR/p70 S6K in these cases were detected using the SP method of immunohisto- chemistry. The correlation between their expressions in OSCC was also analyzed.
Results: The positive expressions ofp-Akt, p-mTOR, and p70 S6K in OSCC were significantly higher than those in normal oral mucosa and paracancerous mucosa. The expressions of p-Akt, p-mTOR, and p70 S6K in OSCC were not correlated with age, gender, and clinical stage; by comparison, these expressions were correlated with lymph node metastasis and pathological grade. Strong positive correlations were also observed between the expressions ofp-Akt, p-mTOR, and p70 S6K in OSCC.
Conclusion: Akt/mTOR/p70 S6K signaling molecules exhibit active expressions in OSCC and may be implicated in the occurrence and development of OSCC.
目的: 探讨丝/苏氨酸蛋白激酶（Akt）/哺乳动物雷帕霉素靶蛋白（mTOR）/p70 S6K信号通路在口腔鳞癌组织中的表达情况，为口腔鳞癌的早期诊断和治疗提供参考。
方法: 收集口腔鳞癌标本51例，癌旁黏膜组织10例，正常口腔黏膜10例。采用免疫组织化学SP法检测口腔鳞癌、癌旁黏膜组织及正常口腔黏膜中p-Akt、p-mTOR及p70 S6K的表达情况，分析三者相互之间表达的相关性。
结果: p-Akt、p-mTOR及p70 S6K在口腔鳞癌组中的表达显著高于正常口腔黏膜组和癌旁黏膜组的表达。p-Akt、p-mTOR及p70 S6K在口腔鳞癌的表达与患者的年龄、性别及临床分期无相关性，但与口腔鳞癌的分化程度及有无淋巴结转移有相关性。p-Akt、p-mTOR及p70 S6K在口腔鳞癌的表达相互之间具有较强的正相关关系。
结论: Akt/mTOR/p70 S6K信号通路分子在口腔鳞癌中表达活跃，提示可能与口腔鳞癌的发生发展具有重要的相关性。