Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression

Chin Chiang; Rebecca A Ihrie

doi:10.1016/j.ccell.2014.11.020

Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression

Cancer Cell. 2014 Dec 8;26(6):773-774. doi: 10.1016/j.ccell.2014.11.020.

Authors

Chin Chiang¹, Rebecca A Ihrie²

Affiliations

¹ Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: chin.chiang@vanderbilt.edu.
² Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA; Department of Neurological Surgery, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: rebecca.ihrie@vanderbilt.edu.

PMID: 25490438
DOI: 10.1016/j.ccell.2014.11.020

Abstract

In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from proliferative precursor cell to a more differentiated immature neuron through repressing the expression of Hedgehog effectors, thus controlling a pathway that is aberrantly activated in medulloblastoma.

Publication types

Comment

MeSH terms

Animals
DNA-Binding Proteins / metabolism*
Humans
Medulloblastoma / pathology*
Neurogenesis*
Proto-Oncogene Proteins / metabolism*
Proto-Oncogene Proteins c-bcl-6
Repressor Proteins / metabolism*
Signal Transduction*
Sirtuin 1 / metabolism*

Substances

BCL6 protein, human
BCOR protein, human
DNA-Binding Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-6
Repressor Proteins
Sirtuin 1

Grants and funding

R01 NS042205/NS/NINDS NIH HHS/United States