This paper describes an innovative architecture for the remote follow-up of the health of chronic patients, and its implementation which is called Hygehos Home. The main purpose of the system is to enhance the quality of the daily healthcare practice, by means of bringing both patient and medical professionals closer to each other and by empowering the patient in the healing process. On the one side, Hygehos Home is a platform which gives the patient access to a set of personalized e-Health services using different channels such as web or smartphone. The e-Health services currently provided are: a) health related questionnaires, b) vital sign delivery (weight, blood pressure, oxygen level in blood, temperature, etc.), c) pharmacologic treatment adherence follow-up, d) access to information about the disease, and e) direct communication with the care providers (physicians, nurses, etc.). On the other side, Hygehos Home is fully integrated in the Hospital Information System (HIS), so that the healthcare professionals can easily access all data registered by the patients, such as subjective feedback, vital signs, medication uptake, etc. In this way, the health professionals are able to conduct an efficient and continuous remote supervision of the evolution of the patient. Finally, the validation protocol being conducted is described.