Well-defined biohybrids using reversible-deactivation radical polymerization procedures

Saadyah Averick; Ryan A Mehl; Subha R Das; Krzysztof Matyjaszewski

doi:10.1016/j.jconrel.2014.11.030

Well-defined biohybrids using reversible-deactivation radical polymerization procedures

J Control Release. 2015 May 10:205:45-57. doi: 10.1016/j.jconrel.2014.11.030. Epub 2014 Dec 4.

Authors

Saadyah Averick¹, Ryan A Mehl², Subha R Das³, Krzysztof Matyjaszewski⁴

Affiliations

¹ Laboratory for Bimolecular Medicine, Allegheny Health Network Research Institute, 320 E. North St., Pittsburgh, PA 15212, USA. Electronic address: saverick@WPAHS.org.
² Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA. Electronic address: Ryan.Mehl@oregonstate.edu.
³ Center for Nucleic Acids Science and Technology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA; Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA. Electronic address: srdas@andrew.cmu.edu.
⁴ Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA. Electronic address: km3b@andrew.cmu.edu.

PMID: 25483427
DOI: 10.1016/j.jconrel.2014.11.030

Abstract

The use of reversible deactivation radical polymerization (RDRP) methods has significantly expanded the field of bioconjugate synthesis. RDRP procedures have allowed the preparation of a broad range of functional materials that could not be realized using prior art poly(ethylene glycol) functionalization. The review of procedures for synthesis of biomaterials is presented with a special focus on the use of RDRP to prepare biohybrids with proteins, DNA and RNA.

Keywords: ATRP; Bioconjugates; Biohybrids; Polymer; RAFT; RDRP.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biocompatible Materials*
Chemistry, Pharmaceutical
DNA / chemistry*
Models, Molecular
Nucleic Acid Conformation
Polymerization
Polymers / chemical synthesis*
Protein Conformation
Proteins / chemistry*
RNA / chemistry*
Technology, Pharmaceutical / methods*

Substances

Biocompatible Materials
Polymers
Proteins
RNA
DNA