Abstract
In the last decade, several mouse models for RhoA, Rac1, and Cdc42 have emerged and have contributed a great deal to understanding the precise functions of Rho GTPases at early stages of development. This review summarizes our current knowledge of various mouse models of tissue-specific ablation of Cdc42, Rac1, and RhoA with emphasis on early embryogenesis, epithelial and skin morphogenesis, tubulogenesis, development of the central nervous system, and limb development.
Keywords:
Cdc42; Rac1; RhoA; cell fate; cell migration; cell polarity; cytoskeleton; embryonic development; mouse models; tubulogenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Embryonic Development*
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Gene Expression Regulation, Developmental
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Mice
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Neuropeptides / genetics
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Neuropeptides / metabolism*
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cdc42 GTP-Binding Protein / genetics
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cdc42 GTP-Binding Protein / metabolism*
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rac1 GTP-Binding Protein / genetics
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rac1 GTP-Binding Protein / metabolism*
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rho GTP-Binding Proteins / genetics
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rho GTP-Binding Proteins / metabolism*
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rhoA GTP-Binding Protein
Substances
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Cdc42 protein, mouse
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Neuropeptides
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Rac1 protein, mouse
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RhoA protein, mouse
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cdc42 GTP-Binding Protein
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rac1 GTP-Binding Protein
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rho GTP-Binding Proteins
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rhoA GTP-Binding Protein