Synthetic fluorescent probes capable of selective recognition of 3'-overhanging nucleotides for siRNA delivery imaging

Chem Commun (Camb). 2015 Jan 28;51(8):1421-4. doi: 10.1039/c4cc08800j.

Abstract

Peptide nucleic acid (PNA)-thiazole orange (TO) conjugates are developed as fluorescent probes capable of selective recognition of 3'-overhanging nucleotides of siRNAs for an accurate analysis of the siRNA delivery process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzothiazoles / administration & dosage*
  • Benzothiazoles / chemistry
  • Diagnostic Imaging
  • Fluorescent Dyes / administration & dosage*
  • Fluorescent Dyes / chemistry
  • HeLa Cells
  • Humans
  • Nucleotides / metabolism*
  • Peptide Nucleic Acids / administration & dosage*
  • Peptide Nucleic Acids / chemistry
  • Quinolines / administration & dosage*
  • Quinolines / chemistry
  • RNA, Small Interfering / administration & dosage*
  • RNA, Small Interfering / chemistry

Substances

  • Benzothiazoles
  • Fluorescent Dyes
  • Nucleotides
  • Peptide Nucleic Acids
  • Quinolines
  • RNA, Small Interfering
  • thiazole orange