PLC and PI3K/Akt/mTOR signalling in disease and cancer

Adv Biol Regul. 2015 Jan:57:10-6. doi: 10.1016/j.jbior.2014.10.004. Epub 2014 Nov 26.

Abstract

Cancer cell metabolism is deregulated, and signalling pathways can be involved. For instance, PI3K/Akt/mTOR is associated with normal proliferation and differentiation, and its alteration is detectable in cancer cells, that exploit the normal mechanisms to overcome apoptosis. On the other hand, also the family of Phospholipase C (PLC) enzymes play a critical role in cell growth, and any change concerning these enzymes or their downstream targets can be associated with neoplastic transformation. Here, we review the role of PLC and PI3K/Akt/mTOR signal transduction pathways in pathophysiology.

Keywords: Nucleus; PI3K/Akt/mTOR; Phospholipase C.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Cell Proliferation*
  • Humans
  • Phosphatidylinositol 3-Kinases / genetics
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Proto-Oncogene Proteins c-akt / genetics
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction*
  • TOR Serine-Threonine Kinases / genetics
  • TOR Serine-Threonine Kinases / metabolism*
  • Type C Phospholipases / genetics
  • Type C Phospholipases / metabolism*

Substances

  • MTOR protein, human
  • Proto-Oncogene Proteins c-akt
  • TOR Serine-Threonine Kinases
  • Type C Phospholipases