Abstract
Transport of proteins containing a nuclear localization signal (NLS) into the nucleus is mediated by nuclear transport receptors called importins, typically dimmers of a cargo-binding α-subunit and a β-subunit that mediates translocation through the nuclear pore complexes (NPCs). However, how proteins without canonical NLS move into the nucleus is not well understood. Recent results indicate that phospholipids, such as phosphatidic acid, play important roles in the intracellular translocation of proteins between the nucleus and cytoplasm.
Keywords:
Arabidopsis; NLS, nuclear localization signal; NPCs, nuclear pore complexes; PA, phosphatidic acid; PLD, phospholipase D.; PtdIns(5)P, Phosphatidylinositol-5-bisphosphate; nuclear localization signal; phosphatidic acid; phospholipid; protein nuclear import.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Active Transport, Cell Nucleus / drug effects
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Arabidopsis / drug effects
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Arabidopsis / metabolism
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Arabidopsis Proteins / metabolism*
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Cell Nucleus / drug effects
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Cell Nucleus / metabolism*
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Intracellular Space / metabolism
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Models, Biological
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Nuclear Localization Signals / metabolism
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Phosphatidic Acids / pharmacology*
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Receptors, Cell Surface / metabolism
Substances
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Arabidopsis Proteins
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Nuclear Localization Signals
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Phosphatidic Acids
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Receptors, Cell Surface
Grants and funding
The work was supported as part of the Center for Advanced Biofuels Systems (CABS), an Energy Frontier Research Center funded by the US. Department of Energy, Office of Science, Basic Energy Sciences under Award DE-SC0001295 and supported by the National Science Foundation (NSF) under Award IOS-0818740. HY acknowledges support by Chinese Scholarship Council.