Stem cell RNA epigenetics: m(6)arking your territory

Aimee L Jalkanen; Jeffrey Wilusz

doi:10.1016/j.stem.2014.11.011

Stem cell RNA epigenetics: m(6)arking your territory

Cell Stem Cell. 2014 Dec 4;15(6):669-70. doi: 10.1016/j.stem.2014.11.011.

Authors

Aimee L Jalkanen¹, Jeffrey Wilusz²

Affiliations

¹ Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
² Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA. Electronic address: jeffrey.wilusz@colostate.edu.

PMID: 25479740
DOI: 10.1016/j.stem.2014.11.011

Abstract

Modifications of mRNAs can have a profound effect on cellular function and differentiation. In this issue of Cell Stem Cell, Batista et al. (2014) describe fundamental parameters of N(6)-methyl-adenosine modification of mRNAs in embryonic stem cells and provide strong evidence that modification plays a role in exit from pluripotency toward differentiation.

Publication types

Comment

MeSH terms

Adenine / analogs & derivatives*
Animals
Embryonic Stem Cells / physiology*
Female
Homeodomain Proteins / metabolism*
Humans
Methyltransferases / metabolism*

Substances

Homeodomain Proteins
Methyltransferases
Adenine