The risk of lung cancer after cessation of asbestos exposure in construction workers using pleural malignant mesothelioma as a marker of exposure

J Occup Environ Med. 2014 Dec;56(12):1297-301. doi: 10.1097/JOM.0000000000000258.

Abstract

Objective: To study the risk of lung cancer in heavily asbestos-exposed workers after the exposure to asbestos has ended.

Methods: Lung cancer was studied in a cohort of 189,896 Swedish construction workers through a linkage with the Swedish Cancer Registry. Asbestos exposure was estimated by the incidence of malignant mesothelioma in the occupational group.

Results: There were in total 2835 cases of lung cancer. Workers with heavy exposure to asbestos had an increased risk of lung cancer (relative risks = 1.74; 95% confidence interval, 1.25 to 2.41) before exposure ended and a similar risk to those with low exposure 20 years after the exposure had ceased (relative risks = 0.94; 95% confidence interval, 0.77 to 1.15).

Conclusions: Workers with heavy exposure to asbestos have a similar risk of lung cancer as persons with low or no exposure 20 years after the exposure has ended.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Asbestos / toxicity*
  • Biomarkers
  • Construction Industry*
  • Humans
  • Incidence
  • Lung Neoplasms / epidemiology*
  • Lung Neoplasms / etiology
  • Male
  • Mesothelioma / epidemiology*
  • Mesothelioma / etiology
  • Middle Aged
  • Occupational Diseases / epidemiology*
  • Occupational Diseases / etiology
  • Occupational Exposure / adverse effects*
  • Pleural Neoplasms / epidemiology*
  • Pleural Neoplasms / etiology
  • Prospective Studies
  • Registries
  • Risk Assessment
  • Sweden / epidemiology

Substances

  • Biomarkers
  • Asbestos