Heterogeneity assessment of histological tissue sections in whole slide images

Comput Med Imaging Graph. 2015 Jun:42:51-5. doi: 10.1016/j.compmedimag.2014.11.006. Epub 2014 Nov 20.

Abstract

Computerized image analysis (IA) can provide quantitative and repeatable object measurements by means of methods such as segmentation, indexation, classification, etc. Embedded in reliable automated systems, IA could help pathologists in their daily work and thus contribute to more accurate determination of prognostic histological factors on whole slide images. One of the key concept pathologists want to dispose of now is a numerical estimation of heterogeneity. In this study, the objective is to propose a general framework based on the diffusion maps technique for measuring tissue heterogeneity in whole slide images and to apply this methodology on breast cancer histopathology digital images.

Keywords: Breast cancer; Dimensionality reduction; Heterogeneity; Spectral graph theory; Whole slide image.

MeSH terms

  • Algorithms
  • Breast Neoplasms / classification*
  • Breast Neoplasms / pathology*
  • Cytodiagnosis / methods*
  • Female
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Microscopy / methods*
  • Pattern Recognition, Automated / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity