A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound

Abstract

A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.

Keywords: brain-blood barrier; focused ultrasound; magnetic guidance; nanobubbles.